OSS_128167 is a potent selective sirtuin 6 ( SIRT6 ) inhibitor with IC 50 s of 89 μM, 1578 μM and 751 μM for SIRT6 , SIRT1 and SIRT2 , respectively. OSS_128167 has anti- HBV activity that inhibits HBV transcription and replication. OSS_128167 has anti-cancer, anti-inflammation and anti-viral effects.
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