GPR109 receptor agonist-1

Overview

GPR109 receptor agonist-1 is a highly selective agonist of the human orphan G protein-coupled receptor GPR109b , and does not activate the mouse homologous receptor PUMA-G . GPR109 receptor agonist-1 functionally modulates the human GPR109b receptor via the cAMP signaling pathway, with an EC 50 of 400 nM. GPR109 receptor agonist-1 inhibits isoproterenol ( HY-B0468 )-stimulated lipolysis in human subcutaneous adipocytes, with efficacy comparable to that of Niacin ( HY-B0143 ), and does not act on β-adrenergic receptors. GPR109 receptor agonist-1 can be used in studies related to dyslipidemia and atherosclerosis.

Application

Products | Products > Disease Areas > Atherosclerosis and Inflammation | Products > Disease Areas > Inflammation or Immune System Disease | Products > Disease Areas > Blood or Cardio-cerebrovascular Disease | Products > Disease Areas > Metabolic or Endocrine Disease | Products > Disease Areas > Chronic Disease and Inflammation | Products > Disease Areas > Cardiovascular Disease | Products > Disease Areas > Lipid Metabolism | Products > Signaling Pathways > GPCR/G Protein | Products > Research Areas > Metabolic Disease | Products > Research Areas > Inflammation/Immunology | Products > Research Areas > Cardiovascular Disease | Products > Signaling Pathways > GPR109A

Product Information

• Catalog No.: HY-107580
• CAS No.: 306935-41-1
• Molecular Formula: C10H11N3O2
• Molecular Weight: 205.22
• Purity: 99.94%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: ≥ 2.5 mg/mL (12.18 mM); Clear solution
• Availability: In-stock

Source

Original product source