Flumethrin (FCR 2769) is a pyrethroid insecticide and acaricide . Flumethrin targets voltage-gated sodium channels and estrogen receptor α ( ERα ) . Flumethrin induces cytotoxicity, apoptosis , genotoxicity and DNA damage in breast cancer cells by regulating the expression of BCL2, BAX , TP53 and P21 genes. Flumethrin is applicable to relevant studies on ectoparasite infections (tick and flea burdens) in dogs and cats, as well as breast cancer .
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