Pregnanediol (NSC 1612) is a Progesterone ( HY-N0437 ) metabolite. Pregnanediol does not affect the transcriptional activity of UGT1A1 enhancer-promoter complex of WT and variant type. pregnanediol inhibits glucuronidation activity of G71R-UGT1A1 . Pregnanediol is a cause of breast milk jaundice in carriers of G71R.
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