PB28

Overview

PB28 is a cyclohexylpiperazine derivative and a high affinity and selective sigma 2 (σ2) receptor agonist with a K i of 0.68 nM. PB28 is also a σ1 antagonist with a K i of 0.38 nM. PB28 is less affinity for other receptors. PB28 inhibits electrically evoked twitch in guinea pig bladder and ileum with EC 50 values of 2.62 μM and 3.96 μM, respectively. PB28 can modulate SARS-CoV-2-human protein-protein interaction. PB28 induces caspase-independent apoptosis and has antitumor activity.

Application

Products | Products > Disease Areas > Infection | Products > Signaling Pathways > Neuronal Signaling | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > Anti-infection | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Immunotherapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Research Areas > Infection | Products > Signaling Pathways > Sigma Receptor | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > SARS-CoV

Product Information

• Catalog No.: HY-108511A
• CAS No.: 172906-90-0
• Molecular Formula: C24H38N2O
• Molecular Weight: 370.57
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source