TNP-ATP triethylammonium

Overview

TNP-ATP triethylammonium is a P2X receptor antagonist with an IC 50 of 0.010 μM for P2X 3 and an IC 50 of 0.062 μM for P2X 2/3 . TNP-ATP triethylammonium acts as an inhibitor of CheA autophosphorylation, with a K i of 0.7 µM. TNP-ATP triethylammonium blocks the functional activation of P2X 1-7 receptors. TNP-ATP triethylammonium attenuates hypoxia-induced IL-1β expression and release. TNP-ATP triethylammonium alleviates visceral pain, and improves hypoxia-induced cognitive impairment, insufficient myelination and neuroinflammation. Binding of TNP-ATP triethylammonium to CheA enhances the fluorescence of the TNP group. TNP-ATP triethylammonium can be used in studies related to visceral pain. NP-ATP triethylammonium can be used in studies related to hypoxia-induced insufficient myelination and cognitive decline.

Application

Products | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Disease Areas > Pain | Products > Signaling Pathways > Membrane Transporter/Ion Channel | Products > Signaling Pathways > Immunology/Inflammation | Products > Signaling Pathways > Others | Products > Research Areas > Neurological Disease | Products > Signaling Pathways > P2X Receptor | Products > Signaling Pathways > Interleukin Related | Products > Signaling Pathways > Fluorescent Dye

Product Information

• Catalog No.: HY-108667
• CAS No.: 61368-63-6
• Molecular Formula: C40H77N12O19P3
• Molecular Weight: 1123.03
• Purity: 98.7%
• Storage: Solution, -20°C, 2 years
• Availability: In-stock

Source

Original product source