Razuprotafib sodium

Overview

Razuprotafib (AKB-9778) sodium is a potent and selective inhibitor of the catalytic activity of VE-PTP (vascular endothelial protein tyrosine phosphatase ) with an IC 50 of 17 pM. Razuprotafib sodium promotes TIE2 activation, enhances ANG1-induced TIE2 activation, and stimulates phosphorylation of signaling molecules in the TIE2 pathway, including AKT , eNOS , and ERK . Razuprotafib sodium inhibits the structurally related phosphatase PTP1B with an IC 50 of 780 nM. Razuprotafib sodium shows excellent selectivity for VE-PTP versus a variety of phosphatases, with the exception of HPTPη (IC 50 =36 pM) and HPTPγ (100 pM).

Application

Products | Products > Disease Areas > Inflammation or Immune System Disease | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Signaling Pathways > Protein Tyrosine Kinase/RTK | Products > Research Areas > Inflammation/Immunology | Products > Signaling Pathways > Phosphatase | Products > Signaling Pathways > Tie

Product Information

• Catalog No.: HY-109041A
• CAS No.: 1809275-69-1
• Molecular Formula: C26H25N4NaO6S3
• Molecular Weight: 608.68
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source