Elsulfavirine (R-1206) is an orally active human carbonic anhydrase ( carbonic anhydrase , CA ) inhibitor and an allosteric inhibitor of HIV-1 non-nucleoside reverse transcriptase ( NNRT ). Elsulfavirine also targets and blocks the interaction between adenylosuccinate lyase ( ADSL ) and insulin-induced gene proteins INSIG1/2 , blocks SREBP-1 -mediated de novo lipid synthesis, and inhibits the proliferation of liver cancer cells. The combination of Elsulfavirine and Lenvatinib ( HY-10981 ) produces a synergistic anti-tumor effect. Elsulfavirine is converted into the active metabolite VM1500A in vivo, blocks the DNA polymerase activity of reverse transcriptase , and inhibits HIV-1 replication. Elsulfavirine exhibits a K i of 1960 nM-52400 nM against human carbonic anhydrase isoforms including I, VII, VI, VA, VB, IX, XIII, XIV . Elsulfavirine is used in studies related to HIV-1 infection and liver cancer .
Products | Products > Disease Areas > Infection | Products > Disease Areas > Digestive System Disease | Products > Disease Areas > Liver Cancer | Products > Disease Areas > Digestive System Cancer | Products > Disease Areas > Viral Infection | Products > Disease Areas > Cancer | Products > Signaling Pathways > Others | Products > Signaling Pathways > Anti-infection | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Research Areas > Infection | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Immunotherapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > Drug Intermediate | Products > Signaling Pathways > HIV | Products > Signaling Pathways > Reverse Transcriptase | Products > Signaling Pathways > Carbonic Anhydrase
Please leave a message for us or use the following ways to contact us, we will reply to you as soon as possible, and provide you with the most sincere service, thank you.
日本语
한국어
Français
Deutsch
España
Türkiye