Obatoclax (GX15-070), a BH3 mimetic, is a pan- BCL-2 family proteins inhibitor with a K i of 220 nM for BCL-2 . Obatoclax induces autophagy -dependent cell death and targets cyclin D1 for proteasomal degradation. Obatoclax has anti-cancer and broad-spectrum antiparasitic activity.
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