VU590 dihydrochloride is a potent and moderately selective ROMK (Kir1.1) inhibitor, with an IC 50 of 290 nM. VU590 also inhibits Kir7.1 , with an IC 50 of 8 μM. VU590 dihydrochloride is not a good probe of ROMK function in the kidney.
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