(S)-PFI-2 hydrochloride

Overview

(S)-PFI-2 hydrochloride is an inhibitor of lysine methyltransferase SETD7 and is approximately 500-fold more active than its enantiomer (R)-PFI-2. (R)-PFI-2 is a cofactor-dependent and substrate-competitive inhibitor. (R)-PFI-2 can occupy the substrate peptide binding groove of SETD7 (including the catalytic lysine binding channel) and interact with the cofactor The donor methyl group is in direct contact. However, (S)-PFI-2 was not observed to have the same interaction as (R)-PFI-2.

Application

Products | Products > Signaling Pathways > Epigenetics | Products > Research Areas > Others | Products > Signaling Pathways > Histone Methyltransferase

Product Information

• Catalog No.: HY-110196
• CAS No.: 1627607-88-8
• Molecular Formula: C23H26ClF4N3O3S
• Molecular Weight: 535.98
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.
• Availability: In-stock

Source

Original product source