Metformin-d 6 hydrochloride

Overview

Metformin-d 6 hydrochloride is a deuterium labeled Metformin hydrochloride. Metformin hydrochloride inhibits the mitochondrial respiratory chain in the liver, leading to AMPK activation and enhancing insulin sensitivity, and can be used in the study of type 2 diabetes. Metformin hydrochloride also inhibits liver oxidative stress, nitrosative stress, inflammation, and apoptosis caused by liver ischemia/reperfusion injury. In addition, metformin hydrochloride regulates the expression of autophagy -related proteins by activating AMPK and inhibiting the mTOR signaling pathway, thereby inducing tumor cell autophagy and inhibiting the growth of renal cell carcinoma in vitro and in vivo.

Application

Products | Products > Disease Areas > Blood or Cardio-cerebrovascular Disease | Products > Disease Areas > Metabolic or Endocrine Disease | Products > Signaling Pathways > Others | Products > Signaling Pathways > Epigenetics | Products > Signaling Pathways > PI3K/Akt/mTOR | Products > Signaling Pathways > Autophagy | Products > Signaling Pathways > Apoptosis | Products > Research Areas > Metabolic Disease | Products > Research Areas > Cardiovascular Disease | Products > Signaling Pathways > Mitophagy | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > mTOR | Products > Signaling Pathways > Isotope-Labeled Compounds | Products > Signaling Pathways > AMPK | Products > Signaling Pathways > Autophagy

Product Information

• Catalog No.: HY-110228
• CAS No.: 1185166-01-1
• Molecular Formula: C4H6D6ClN5
• Molecular Weight: 171.66
• Purity: 99.98%
• Storage: 4°C, sealed storage, away from moisture * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
• Solubility: ≥ 2.08 mg/mL (12.12 mM); Clear solution
• Availability: In-stock

Source

Original product source