CGP 31523A is a broad-spectrum aminothiazole cephalosporin. CGP 31523A exhibits potent inhibitory effects on Enterobacteriaceae , Neisseria , Haemophilus influenzae , and Streptococcus (except Enterococcus faecalis ), among others . CGP 31523A can be hydrolyzed by the common Escherichia coli type Ic β-lactamase, but is stable against the Ia type enzyme. CGP 31523A is neither an effective β-lactamase inhibitor nor does it induce the production of β-lactamase. CGP 31523A can be used for studying infections caused by Gram-negative bacteria (including drug-resistant strains).
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