YM-355179 fumarate

Overview

YM-355179 fumarate is a newly synthesized selective CCR3 antagonist with the potential to inhibit eosinophil-related allergic inflammatory diseases. YM-355179 can effectively inhibit the binding of CCL11 and CCL5 to CCR3-expressing cells, with IC 50 values of 7.6 nM and 24 nM respectively. In functional experiments, YM-355179 can inhibit CCL11-induced intracellular Ca (2+) influx, chemotaxis and eosinophil degranulation, IC 50 The values are 8.0 nM, 24 nM and 29 nM respectively.

Application

Products | Products > Disease Areas > Inflammation or Immune System Disease | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Research Areas > Inflammation/Immunology | Products > Signaling Pathways > Endogenous Metabolite

Product Information

• Catalog No.: HY-111198
• CAS No.: 887647-69-0
• Molecular Formula: C33H35FN4O7
• Molecular Weight: 618.65
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source