JH-XI-10-02

Overview

JH-XI-10-02 is a PROTAC connected by ligands for Cereblon and CDK . JH-XI-10-02 is a highly potent and selective PROTAC CDK8 degrader, with an IC 50 of 159 nM. JH-XI-10-02 causes proteasomal degradation, does not affect CDK8 mRNA levels. JH-XI-10-02 shows no effect on CDK19 . (Pink: CDK8 ligand ( HY-184544 ); Blue: Cereblon ligand ( HY-10984 ); Black: linker ( HY-117104 )).

Application

Products | Products > Disease Areas > Cancer | Products > Signaling Pathways > PROTAC | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Immunotherapy | Products > Signaling Pathways > PROTACs | Products > Signaling Pathways > CDK

Product Information

• Catalog No.: HY-111518
• CAS No.: 2209085-22-1
• Molecular Formula: C53H69N5O9
• Molecular Weight: 920.14
• Purity: 99.73%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: ≥ 5.75 mg/mL (6.25 mM); Clear solution
• Availability: In-stock

Source

Original product source