BI-3663

Overview

BI-3663 is a highly selective PTK2/FAK PROTAC ( DC 50 = 30 nM) with a Cereblon E3 ligase ligand capable of degrading PTK2, with an IC 50 value of 18 nM. BI-3663 is a PROTAC generated by linking the PTK2/FAK inhibitor BI-4464 ( HY-124625 ) with a Pomalidomide ( HY-10984 ) derivative via a linker. BI-3663 can induce PTK2 degradation at low nanomolar concentrations. BI-3663 has antitumor activity. (Pink: FAK ligand ( HY-43760 ); Blue: Cereblon ligand ( HY-10984 ); Black: linker ( HY-42490 )).

Application

Products | Products > Disease Areas > Cancer | Products > Disease Areas > Lung Cancer | Products > Signaling Pathways > PROTAC | Products > Signaling Pathways > Protein Tyrosine Kinase/RTK | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Signaling Pathways > PROTACs | Products > Signaling Pathways > FAK

Product Information

• Catalog No.: HY-111546
• CAS No.: 2341740-84-7
• Molecular Formula: C44H42F3N7O12
• Molecular Weight: 917.84
• Purity: 99.84%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
• Solubility: ≥ 7.5 mg/mL (8.17 mM); Clear solution
• Availability: In-stock

Source

Original product source