VUBI1

Overview

VUBI1 (SOS1 activator 1) is a benzimidazole derivative and SOS1 activator with a K d of 44 nM. VUBI1 can significantly activate RAS-GTP and regulate the phosphorylation of ERK . VUBI1 also can serve as a target ligand for synthesizing PROTACs , such as PROTAC SOS1 degrader-1 ( HY-145737 ), to induce SOS1 degradation. VUBI1 can be used in the study of cancer .

Application

Products | Products > Disease Areas > Cancer | Products > Signaling Pathways > GPCR/G Protein | Products > Signaling Pathways > MAPK/ERK Pathway | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Signaling Pathways > PROTAC | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > SOS1 | Products > Signaling Pathways > Ras | Products > Signaling Pathways > PERK | Products > Signaling Pathways > Ligands for Target Protein for PROTAC

Product Information

• Catalog No.: HY-111671
• CAS No.: 2245237-53-8
• Molecular Formula: C26H32ClFN6
• Molecular Weight: 483.02
• Purity: 98.21%
• Storage: 4°C, protect from light * In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
• Availability: In-stock

Source

Original product source