DMX-5804

Overview

DMX-5804 is a potent, orally active and selective MAP4K4 inhibitor, with an IC 50 of 3 nM, a pIC 50 of 8.55 for human MAP4K4, less potent on MINK1/MAP4K6 ( pIC 50 , 8.18), and TNIK/MAP4K7 ( pIC 50 , 7.96). DMX-5804 enhances cardiomyocyte survival, and reduces ischemia-reperfusion injury in mice.

Application

Products | Products > Disease Areas > Blood or Cardio-cerebrovascular Disease | Products > Disease Areas > Metabolic or Endocrine Disease | Products > Disease Areas > Lipid Metabolism | Products > Disease Areas > Cardiovascular Disease | Products > Disease Areas > Obesity | Products > Signaling Pathways > MAPK/ERK Pathway | Products > Research Areas > Cardiovascular Disease | Products > Signaling Pathways > MAP4K

Product Information

• Catalog No.: HY-111754
• CAS No.: 2306178-56-1
• Molecular Formula: C21H19N3O3
• Molecular Weight: 361.39
• Purity: 99.64%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
• Solubility: ≥ 2.5 mg/mL (6.92 mM); Clear solution
• Availability: In-stock

Source

Original product source