PROTAC RAR Degrader-1

Overview

PROTAC RAR degrader-1 (Compound 9) is a potent and selective RAR PROTAC Degrader consisting of apoptotic protein inhibitors ( IAPs ) ligands. IAPs-based degraders are also known as SNIPERs . PROTAC RAR Degrader-1 reduces RARα levels in HT1080 cells in a concentration-dependent manner but is blocked by the proteasome inhibitor MG132 ( HY-13259 ). PROTAC RAR Degrader-1 can be used in the study of nuclear receptor-related diseases. (Pink: RAR ligand 1 ( HY-111843 ); Black: Linker ( HY-140189 ); Blue: IAPs Ligand ( HY-B0134 )).

Application

Products | Products > Disease Areas > Metabolic or Endocrine Disease | Products > Disease Areas > Cancer | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Signaling Pathways > PROTAC | Products > Signaling Pathways > Vitamin D Related/Nuclear Receptor | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Research Areas > Neurological Disease | Products > Research Areas > Metabolic Disease | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > PROTACs | Products > Signaling Pathways > SNIPERs | Products > Signaling Pathways > RAR/RXR

Product Information

• Catalog No.: HY-111844
• CAS No.: 1351169-27-1
• Molecular Formula: C51H72N4O11
• Molecular Weight: 917.14
• Purity: 97.91%
• Storage: -20°C, stored under nitrogen * In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
• Solubility: ≥ 2 mg/mL (2.18 mM); Clear solution
• Availability: In-stock

Source

Original product source