SNIPER(BRD)-1

Overview

SNIPER (BRD)-1 is a BRD2/3/4 SNIPER degrader. SNIPER (BRD)-1 induces ubiquitin-proteasome-dependent degradation of the epigenetic regulatory proteins BRD2/3/4 as well as the IAP family E3 ligase itself with its IC 50 values for cIAP1 , cIAP2 and XIAP of 6.8 nM, 17 nM and 49 nM, respectively. SNIPER (BRD)-1 can be used in the research of prostate cancer . (Pink: BRD4 ligand ( HY-13030 ); Blue: IAP ligand ( HY-15518 ); Black: linker ( HY-W008005 )).

Application

Products | Products > Disease Areas > Cancer | Products > Disease Areas > Urogenital Disease | Products > Disease Areas > Prostate Cancer | Products > Disease Areas > Urogenital Cancer | Products > Signaling Pathways > PROTAC | Products > Signaling Pathways > Epigenetics | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > SNIPERs | Products > Signaling Pathways > Epigenetic Reader Domain

Product Information

• Catalog No.: HY-111875
• CAS No.: 2095244-54-3
• Molecular Formula: C53H66ClN9O8S2
• Molecular Weight: 1056.73
• Purity: 99.68%
• Storage: -20°C, stored under nitrogen * In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
• Solubility: ≥ 2.5 mg/mL (2.37 mM); Clear solution
• Availability: In-stock

Source

Original product source