SCYX-6759 is an orally active, blood-brain barrier permeable anti- T. brucei agent. SCYX-6759 inhibits cytochrome P450 ( IC 50 s: 30.3, 30.6, 47.4 μM for 2D6, 2C9, 2C19, respectively.) SCYX-6759 exhibits potent activity against T. b. brucei 427, T. b. rhodesiense STIB900, and T. b. gambiense STIB930, with IC 50 s of 0.07, 0.038 and 0.030 μg/mL, respectively.
Products | Products > Disease Areas > Infection | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Signaling Pathways > Anti-infection | Products > Research Areas > Infection | Products > Signaling Pathways > Cytochrome P450 | Products > Signaling Pathways > Parasite
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