GSK180

Overview

GSK180 is a selective, competitive, and potent inhibitor of kynurenine-3-monooxygenase ( KMO ) , a key enzyme of tryptophan metabolism ( IC 50 , ~6 nM), but shows negligible activity against other enzymes on the tryptophan pathway. GSK180 rapidly changes levels of kynurenine pathway metabolites, and acts as a useful tool to probe the therapeutic potential of KMO inhibition.

Application

Products | Products > Disease Areas > Inflammation or Immune System Disease | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Research Areas > Inflammation/Immunology | Products > Signaling Pathways > KMO

Product Information

• Catalog No.: HY-112179
• CAS No.: 1799725-26-0
• Molecular Formula: C10H7Cl2NO4
• Molecular Weight: 276.07
• Purity: 98.34%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
• Solubility: ≥ 2.08 mg/mL (7.53 mM); Clear solution
• Availability: In-stock

Source

Original product source