NF449

Overview

NF449 is a highly potent P2X 1 receptor antagonist, with IC 50 s of 0.28, 0.69, and 120 nM for rP2X 1 , rP2X 1+5 , P2X 2+3 , respectively. NF449 is a G sα -selective G Protein antagonist. NF449 suppresses the rate of GTP[γS] binding to G sα-s , inhibits the stimulation of adenylyl cyclase activity, and blocks the coupling of β-adrenergic receptors to G s .

Application

Products | Products > Disease Areas > Blood or Cardio-cerebrovascular Disease | Products > Signaling Pathways > Membrane Transporter/Ion Channel | Products > Research Areas > Cardiovascular Disease | Products > Signaling Pathways > P2X Receptor

Product Information

• Catalog No.: HY-112461
• CAS No.: 389142-38-5
• Molecular Formula: C41H32N6O29S8
• Molecular Weight: 1329.24
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source