NF449 octasodium

Overview

NF449 octasodium is a highly potent P2X 1 receptor antagonist, with IC 50 s of 0.28, 0.69, and 120 nM for rP2X 1 , rP2X 1+5 , P2X 2+3 , respectively. NF449 octasodium is a G sα -selective G Protein antagonist. NF449 octasodium suppresses the rate of GTP[γS] binding to G sα-s , inhibits the stimulation of adenylyl cyclase activity, and blocks the coupling of β-adrenergic receptors to G s .

Application

Products | Products > Disease Areas > Blood or Cardio-cerebrovascular Disease | Products > Disease Areas > Cardiovascular Disease | Products > Signaling Pathways > Membrane Transporter/Ion Channel | Products > Research Areas > Cardiovascular Disease | Products > Signaling Pathways > P2X Receptor

Product Information

• Catalog No.: HY-112461A
• CAS No.: 627034-85-9
• Molecular Formula: C41H24N6Na8O29S8
• Molecular Weight: 1505.09
• Purity: 97.39%
• Storage: -20°C, stored under nitrogen * In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
• Availability: In-stock

Source

Original product source