LEI105

Overview

LEI105 is a highly selective and reversible diacylglycerol lipase ( DAGL ) inhibitor that exhibits significant inhibitory activity against human DAGLα and DAGLβ (e.g., the pIC 50 value against human DAGLα is 8.5, and the IC 50 against human DAGLβ is 32 nM). LEI105 effectively reduces intracellular 2-arachidonoylglycerol levels and inhibits CB1 receptor-mediated short-term synaptic plasticity. LEI105 can be used to investigate the on-demand biosynthesis of 2-AG in retrograde signaling.

Application

Products | Products > Disease Areas > Metabolic or Endocrine Disease | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Research Areas > Metabolic Disease | Products > Signaling Pathways > DAGL

Product Information

• Catalog No.: HY-112828
• CAS No.: 1800327-36-9
• Molecular Formula: C25H24N2O2
• Molecular Weight: 384.47
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source