Desmosterol is a cholesterol-like molecule. In the Bloch pathway of cholesterol biosynthesis, Desmosterol is a direct precursor of cholesterol . As an endogenous metabolite , Desmosterol is used to study cholesterol metabolism . Desmosterol is an LXR activator and SREBP inhibitor, which can suppress macrophage inflammasome activation and prevent vascular inflammation and atherosclerosis. A reduction in Desmosterol promotes the production of mitochondrial reactive oxygen species ( ROS ) in macrophages and pyrin domain-dependent inflammasome activation of NLRP3 . Desmosterol holds potential for research in inflammation, metabolism, and cardiovascular diseases .
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