Ap4A tetraammonium (P1,P4-Di-(adenosine-5')-tetraphosphate tetraammonium) is a conserved second messenger in organisms ranging from bacteria to humans. Ap4A tetraammonium binds to the histidine triad nucleotide-binding protein 1 ( HINT1 ) activates the transcription of genes downstream of MITF. Ap4A tetraammonium induces apoptosis .
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