Leukotriene E4-d 5

Overview

Leukotriene E4 -d 5 (LTE4-d 5 ) is the d- 5 -labeled Leukotriene E4 ( HY-113465 ). Leukotriene E4 is a stable final metabolite of cysteinyl leukotrienes, produced by immune cells such as mast cells and eosinophils. Leukotriene E4 serves as a key biomarker for evaluating asthma severity, Aspirin ( HY-14654 ) sensitivity, and mast cell activation disorders. Leukotriene E4 is a full functional agonist of CysLT 1 R , which induces sustained intracellular calcium mobilization and Erk phosphorylation. Leukotriene E4 mediates inflammation in a P2Y 12 receptor -dependent manner. Leukotriene E4 can be used in the research of asthma and non-steroidal anti-inflammatory drug-exacerbated respiratory diseases.

Application

Products | Products > Disease Areas > Inflammation or Immune System Disease | Products > Disease Areas > Respiratory Disease | Products > Disease Areas > Lower Respiratory Inflammation | Products > Disease Areas > Respiratory Inflammation | Products > Disease Areas > Asthma | Products > Signaling Pathways > Others | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Signaling Pathways > GPCR/G Protein | Products > Signaling Pathways > Membrane Transporter/Ion Channel | Products > Signaling Pathways > Neuronal Signaling | Products > Signaling Pathways > Stem Cell/Wnt | Products > Signaling Pathways > MAPK/ERK Pathway | Products > Research Areas > Inflammation/Immunology | Products > Signaling Pathways > Endogenous Metabolite | Products > Signaling Pathways > Leukotriene Receptor | Products > Signaling Pathways > Calcium Channel | Products > Signaling Pathways > ERK | Products > Signaling Pathways > P2Y Receptor | Products > Signaling Pathways > Isotope-Labeled Compounds

Product Information

• Catalog No.: HY-113465S
• CAS No.: 1240398-14-4
• Molecular Formula: C23H32D5NO5S
• Molecular Weight: 444.64
• Purity: 98.5%
• Storage: Solution, -20°C, 2 years
• Availability: In-stock

Source

Original product source