3-O-Methyldopa -d 3 (3-Methoxy-L-tyrosine-d 3 ) is deuterium labeled 3-O-Methyldopa ( HY-113468A ). 3-O-Methyldopa (3-Methoxy-L-tyrosine) is a metabolite of L-DOPA ( HY-N0304 ) that can cross the blood-brain barrier (BBB). 3-O-Methyldopa inhibits the astrocyte-mediated protective effect of L-DOPA ( HY-N0304 ) on dopaminergic neurons. In addition, 3-O-Methyldopa has certain antidepressant and neuroprotective activities. 3-O-Methyldopa can be used in the research of nervous system diseases such as depression and Parkinson's disease.
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