FKBP12 PROTAC dTAG-13

CAS No.：2064175-41-1
Grade：99.89%
Formula：C57H68N4O15
M.W.：1049.17
Solvent：≥ 2.5 mg/mL (2.38 mM); Clear solution

Important Notice

This product is a chemical product/pharmaceutical intermediate. It is not a drug, an active pharmaceutical ingredient (API), or a pharmaceutical-grade material. It has not been granted a drug approval number or a Chemical Drug Substance Approval Notice, has not passed drug-related review and approval, and is not manufactured, tested, or released in accordance with pharmaceutical GMP.
This product is intended solely for non-clinical research, process development, quality studies, further chemical processing, or chemical synthesis. It must not be used in drug-product manufacturing, clinical trials, clinical diagnosis, or administration to humans or animals, or be sold, used as an input, submitted for regulatory filing, or released as an API or pharmaceutical material.
The purchaser must not use this product, or supply it to another party, for personal consumption, sports or fitness, weight loss, health supplements, food, or animal feed.

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Overview

FKBP12 PROTAC dTAG-13 (dTAG-13) is a FKBP12 F36V PROTAC degrader and a PXR partial agonist. FKBP12 PROTAC dTAG-13 induces ubiquitination and proteasomal degradation of proteins tagged with FKBP12 F36V , without degrading wild-type FKBP12 or un-fused PXR . It weakly promotes the recruitment of SRC-1 , strongly inhibits the interaction between NCoR and PXR , and upregulates the expression of CYP3A4 and other drug metabolism-related genes. FKBP12 PROTAC dTAG-13 is applicable to research related to breast cancer and leukemia [1] . (Pink: FKBP12F36V ligand ( HY-114420 ); Blue: Cereblon ligand ( HY-103596 ); Black: linker).

Application

Products | Products > Disease Areas > Cancer | Products > Signaling Pathways > PROTAC | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Signaling Pathways > Autophagy | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > Immunology/Inflammation | Products > Signaling Pathways > Vitamin D Related/Nuclear Receptor | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Immunotherapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > Pregnane X Receptor (PXR) | Products > Signaling Pathways > PROTACs | Products > Signaling Pathways > FKBP

Product Information

Catalog No.: HY-114421
CAS No.: 2064175-41-1
Molecular Formula: C57H68N4O15
Molecular Weight: 1049.17
Purity: 99.89%
Storage: Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
Solubility: ≥ 2.5 mg/mL (2.38 mM); Clear solution
Availability: In-stock

Source

Original product source

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