Amquinate is a coccidiostat and a cytochrome b inhibitor. Amquinate blocks cytochrom e -mediated electron transport near cytochrome b in mitochondria, acting downstream of coenzyme Q without affecting succinate dehydrogenase or NADH dehydrogenase. Amquinate inhibits succinate- and malate plus pyruvate-supported mitochondrial respiration in Eimeria tenella and does not affect L-ascorbate-supported respiration or any mitochondrial respiration in chicken liver mitochondria. Amquinate exhibits selective anticoccidial activity against wild-type Eimeria tenella . Amquinate can be used for the research of coccidiosis ( Eimeria tenella infection ).
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