tHGA

Overview

tHGA is a compound with anti-inflammatory activity and has the activity to inhibit soybean 15-LOX . tHGA showed significant inhibitory effects in experiments on human leukocytes, with an IC 50 value of 0.42 μM, which is close to the effect of commonly used standard NDGA. tHGA concentration-dependently inhibits the synthesis of 5-LOX products, especially the cysteine leukotriene LTC(4), with an IC 50 value of 1.80 μM. and showed no cytotoxicity. The anti-inflammatory effects of tHGA do not appear to be through redox or metal chelation mechanisms, as the compound was negative in these bioactivity tests. tHGA works through a dual LOX/COX inhibition mechanism and has higher selectivity for 5-LOX and COX-2 , with an IC 50 value of 0.40 μM.

Application

Products | Products > Disease Areas > Inflammation or Immune System Disease | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Research Areas > Inflammation/Immunology | Products > Signaling Pathways > Lipoxygenase

Product Information

• Catalog No.: HY-114796
• CAS No.: 43230-43-9
• Molecular Formula: C18H24O4
• Molecular Weight: 304.38
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source