15-Deoxy-Δ12,14-Prostaglandin D2-d 4 (15-Deoxy-Δ12,14-PGD2-d 4 ) is the deuterium labeled 15-deoxy-Δ12,14-Prostaglandin D2. 15-deoxy-Δ12,14-Prostaglandin D2 (15-Deoxy-Δ12,14-PGD2) is a metabolite of prostaglandin D₂ (PGD₂) ( HY-101988 ), which can undergo further dehydration metabolism to 15-deoxy-Δ12,14-PGJ₂. 15-deoxy-Δ12,14-Prostaglandin D2 is a highly selective agonist for DP2 receptor and PPARγ . 15-deoxy-Δ12,14-Prostaglandin D2 causes morphological changes in eosinophils and migration of type II innate lymphoid cells (ILC2). 15-deoxy-Δ12,14-Prostaglandin D2 has a growth inhibitory effect on prostate cancer cells expressing PPARγ , induces cell cycle arrest and promotes apoptosis . 15-deoxy-Δ12,14-Prostaglandin D2 can be used in related research on asthma and prostate cancer .
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