MAGL-IN-12

MAGL-IN-12
  • CAS No.:1352011-38-1
  • Grade:99.98%
  • Formula:C16H17ClF6N2O4S
  • M.W.:482.83

Important Notice

  1. This product is a chemical product/pharmaceutical intermediate. It is not a drug, an active pharmaceutical ingredient (API), or a pharmaceutical-grade material. It has not been granted a drug approval number or a Chemical Drug Substance Approval Notice, has not passed drug-related review and approval, and is not manufactured, tested, or released in accordance with pharmaceutical GMP.
  2. This product is intended solely for non-clinical research, process development, quality studies, further chemical processing, or chemical synthesis. It must not be used in drug-product manufacturing, clinical trials, clinical diagnosis, or administration to humans or animals, or be sold, used as an input, submitted for regulatory filing, or released as an API or pharmaceutical material.
  3. The purchaser must not use this product, or supply it to another party, for personal consumption, sports or fitness, weight loss, health supplements, food, or animal feed.

Overview

SAR127303 is an orally active, selective, competitive monoacylglycerol lipase ( MAGL ) covalent inhibitor with IC 50 s of 3.8 nM and 29 nM for mouse and human MAGL , respectively. SAR127303 potently elevates hippocampal levels of 2-AG in mice. SAR127303 decreased long term potentiation (LTP) of CA1 synaptic transmission and acetylcholine release in the hippocampus. SAR127303 produces antinociceptive effects in assays of inflammatory and visceral pain. SAR127303 slows down epileptogenesis.

Application

Products | Products > Disease Areas > Metabolic or Endocrine Disease | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Research Areas > Metabolic Disease | Products > Signaling Pathways > MAGL

Product Information

  • Catalog No.: HY-116143
  • CAS No.: 1352011-38-1
  • Molecular Formula: C16H17ClF6N2O4S
  • Molecular Weight: 482.83
  • Purity: 99.98%
  • Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source


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