RO5487624, an analogue of RO5464466 ( HY-120690 ), is an orally active hemagglutinin ( HA ) inhibitor of influenza H1N1 viruses that abolishes influenza virus fusion by blocking HA conformational changes in low pH environments. RO5487624 displays a protective effect on mice that are lethally challenged with influenza H1N1 virus.
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