GCA-186 is a potent anti-HIV-1 agent. GCA-186 is highly active against both wild type and mutated HIV-1 strains with EC 50 s of 1, 180, 1, and 40 nM for III B , III B-R(Y181C) , NL4-3 and NL4-3 K103N of HIV-1 strains, respectively.
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