L 738372

Overview

L-738372 is a non-competitive reversible inhibitor of HIV-1 reverse transcriptase ( RT ) with an inhibition constant ( K i ) of 140 nM against dTTP. When combined with any nucleoside analogs (such as azidothymidine triphosphate, didexoyinosine triphosphate, or didexoycytidine triphosphate), L-738372 exhibits synergistic inhibition of RT activity. L-738372 has 2-3 times more inhibitory potency against the azidothymidine-resistant RT (D67N, K70R, T215Y, K219Q) compared to the wild-type RT . L-738372 holds promise for research in the field of HIV virus treatment.

Application

Products | Products > Disease Areas > Infection | Products > Signaling Pathways > Anti-infection | Products > Research Areas > Infection | Products > Signaling Pathways > HIV

Product Information

• Catalog No.: HY-116973
• CAS No.: 159565-60-3
• Molecular Formula: C18H15N3O
• Molecular Weight: 289.33
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source