Tetraconazole is a selective irreversible inhibitor of 14-α-sterol demethylase ( CYP51 ) with antifungal activity. Tetraconazole competitively binds to the enzyme to block fungal ergosterol synthesis, resulting in cell membrane damage. The EC 50 of tetraconazole against wheat pathogens is 0.382-0.802 mg/L, and the EC 50 against onion root tip meristem cell growth is 6.7 mg/L, and (R)-(+)-Tetraconazole is 1.49-1.98 times more active than (S)-(-)-Tetraconazole. Tetraconazole can also induce oxidative stress and chromosomal aberrations in plant cells.
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