PF-04634817

Overview

PF-0463481 is a potent and orally active dual CCR2/CCR5 antagonist with comparable human and rodent CCR2 potency (rat IC 50 =20.8 nM), and displays 10-20 fold less rodent CCR5 potency (rat IC 50 =470 nM). PF-0463481 is safe and well-tolerated and has the potential for the study of diabetic nephropathy.

Application

Products | Products > Disease Areas > Metabolic or Endocrine Disease | Products > Signaling Pathways > GPCR/G Protein | Products > Signaling Pathways > Immunology/Inflammation | Products > Research Areas > Metabolic Disease | Products > Signaling Pathways > CCR

Product Information

• Catalog No.: HY-117621
• CAS No.: 1228111-63-4
• Molecular Formula: C25H36F3N5O3
• Molecular Weight: 511.58
• Purity: 99.98%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: ≥ 2.5 mg/mL (4.89 mM); Clear solution

Source

Original product source