LP-935509

Overview

LP-935509 is an orally active, potent, selective, ATP-competitive and brain-penetrant inhibitor of adaptor protein-2 associated kinase 1 ( AAK1 ) with an IC 50 of 3.3 nM and a K i of 0.9 nM, respectively. LP-935509 is also a potent inhibitor of BIKE ( IC 50 =14 nM) and a modest inhibitor of GAK ( IC 50 =320 nM). LP-935509 shows antinociceptive activity. LP-935509 can be used for neuropathic pain and SARS-CoV-2 research.

Application

Products | Products > Disease Areas > Inflammation or Immune System Disease | Products > Disease Areas > Viral Infection | Products > Disease Areas > Infection | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Signaling Pathways > Neuronal Signaling | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Signaling Pathways > Anti-infection | Products > Research Areas > Neurological Disease | Products > Research Areas > Inflammation/Immunology | Products > Research Areas > Infection | Products > Signaling Pathways > AAK1 | Products > Signaling Pathways > Cyclin G-associated Kinase (GAK) | Products > Signaling Pathways > SARS-CoV

Product Information

• Catalog No.: HY-117626
• CAS No.: 1454555-29-3
• Molecular Formula: C20H24N6O3
• Molecular Weight: 396.44
• Purity: 99.74%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 1 year , -20°C, 6 months
• Solubility: ≥ 2.08 mg/mL (5.25 mM); Clear solution
• Availability: In-stock

Source

Original product source