S-2720 is a potent inhibitor of both immunodeficiency virus type 1 reverse transcriptase ( HIV-1 RT ) and HIV-1 replication. The binding sites of S-2720 and the nonnucleoside compounds overlap. The small pocket in the p66 subunit-BI-RG-587 ( HY-10570 ) complex is most likely the target of S-2720. S-2720 is a quinoxaline derivative, which is promising for research of HIV-1 infection .
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