Ro 09-1428 is a broad-spectrum parenteral cephalosporin. Ro 09-1428 has potent antibacterial activities against Pseudomonas aeruginosa and Acinetobacter caloaceticus , with MIC90s of 0.39 and 6.25 μg/mL, respectively, better than Ceftazidime ( HY-B0593 ). Additionally, Ro 09-1428 shows high activity against Escherichia coli , Kkbsielia pneumoniae , Proteus mirabilis , P. aeruginosa , staphylococci , and more. Ro 09-1428 preferentially attacks PBP 3 for target in E. coli and P. aeruginosa , which is promising for research of septicemias and serious P. aeruginosa infections.
Products | Products > Disease Areas > Inflammation or Immune System Disease | Products > Signaling Pathways > Anti-infection | Products > Research Areas > Inflammation/Immunology | Products > Research Areas > Infection | Products > Signaling Pathways > Penicillin-binding protein (PBP) | Products > Signaling Pathways > Bacterial
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