Benarthin

Overview

Benarthin is an orally active Pyroglutamyl peptidase inhibitor, THY1 inhibitor (with a K d value of 5.13e-08 M) and competitive PGP-1 inhibitor ( K i = 1.2 µM). Benarthin is isolated from the culture broth of Streptomyces xanthophaeus MJ244-SF1. Benarthin disrupts the THY1 - SFRP1 interaction, inhibits the activation of the GSK3α/β - β-catenin pathway, and reduces the upregulation of FASLG . Benarthin attenuates urothelial anoikis and reduces cell Apoptosis . Benarthin possesses iron-chelating activity. Benarthin maintains urothelial barrier integrity and blocks the pathological cascade of renal interstitial fibroblasts induced by HAP stimulation. Benarthin can be used in studies related to kidney stones.

Application

Products | Products > Disease Areas > Urogenital Disease | Products > Disease Areas > Renal Disease | Products > Disease Areas > Kidney Stones | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Signaling Pathways > Stem Cell/Wnt | Products > Signaling Pathways > PI3K/Akt/mTOR | Products > Signaling Pathways > Apoptosis | Products > Research Areas > Metabolic Disease | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > Aminopeptidase | Products > Signaling Pathways > Endogenous Metabolite | Products > Signaling Pathways > GSK-3 | Products > Signaling Pathways > β-catenin

Product Information

• Catalog No.: HY-117738
• CAS No.: 143651-45-0
• Molecular Formula: C17H25N5O7
• Molecular Weight: 411.41
• Purity: 95.79%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Availability: In-stock

Source

Original product source