mPGES1-IN-7

Overview

mPGES-1-IN-2 (compound III) is a benzimidazole-based mPGES-1 inhibitor that also inhibits adipophysin PGD synthase (I-PGDS) (5 μM, IR=60 %). mPGES-1-IN-2 reduces PGE2 production and tends to reduce levels of other prostaglandins. mPGES-1-IN-2 effectively inhibits acute inflammation in an air sac model stimulated by Carrageenan ( HY-125474 ) in mice.

Application

Products | Products > Disease Areas > Metabolic or Endocrine Disease | Products > Signaling Pathways > Immunology/Inflammation | Products > Research Areas > Endocrinology | Products > Signaling Pathways > PGE synthase

Product Information

• Catalog No.: HY-118282
• CAS No.: 1268709-57-4
• Molecular Formula: C23H34N4O
• Molecular Weight: 382.54
• Purity: 99.78%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: ≥ 2 mg/mL (5.23 mM); Clear solution
• Availability: In-stock

Source

Original product source