AZD-5672

Overview

AZD-5672 is an orally active, potent, and selective CCR5 antagonist ( IC 50 =0.32 nM). AZD-5672 shows moderate activity against the hERG ion channel (binding IC 50 =7.3 μM). AZD5672 is a substrate of human P-gp , and inhibits P-gp-mediated digoxin transport (IC 50 =32 μM). AZD-5672 can be used for the research of rheumatoid arthritis.

Application

Products | Products > Disease Areas > Inflammation or Immune System Disease | Products > Signaling Pathways > Immunology/Inflammation | Products > Signaling Pathways > GPCR/G Protein | Products > Signaling Pathways > Membrane Transporter/Ion Channel | Products > Research Areas > Inflammation/Immunology | Products > Signaling Pathways > CCR | Products > Signaling Pathways > Potassium Channel | Products > Signaling Pathways > P-glycoprotein

Product Information

• Catalog No.: HY-119101
• CAS No.: 780750-65-4
• Molecular Formula: C32H38F2N2O5S2
• Molecular Weight: 632.78
• Purity: 95.74%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Availability: In-stock

Source

Original product source