CP-664511 is an orally active and potent α4β1 integrin antagonist with anti-inflammatory effects ( IC 50 =0.52 nM). CP-664511 inhibits the interaction between α4β1 and vascular cell adhesion molecule-1 (VCAM-1), significantly reducing eosinophil infiltration into lung tissue. CP-664511 is promising for research of asthma and allergic airway diseases.
Products | Products > Disease Areas > Inflammation or Immune System Disease | Products > Signaling Pathways > Cytoskeleton | Products > Research Areas > Inflammation/Immunology | Products > Signaling Pathways > Integrin
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