UK-500001

Overview

UK-500001 is an orally active inhibitor for phosphodiesterase 4 ( PDE4 ), which inhibits PDE4D3 ( IC 50 is 0.28 nM), PDE4B2 ( IC 50 is 22.8 nM), PDE4A4 ( IC 50 is 26.1 nM) and PDE4C2 ( IC 50 is 271 nM). UK-500001 exhibits anti-inflammatory efficacy and inhibits TNF-α and IFN-γ release in human and rodent macrophagic cell lines in nanomolar levels. UK-500001 ameliorates chronic obstructive pulmonary disease (COPD) and asthma.

Application

Products | Products > Disease Areas > Inflammation or Immune System Disease | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Research Areas > Inflammation/Immunology | Products > Signaling Pathways > Phosphodiesterase (PDE)

Product Information

• Catalog No.: HY-119799
• CAS No.: 582332-31-8
• Molecular Formula: C26H24F3N3O4
• Molecular Weight: 499.48
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source