PF-3450074

Overview

PF-3450074 (PF-74) is a specifical inhibitor of HIV-1 capsid protein ( CA ) and displays a broad-spectrum inhibition of HIV isolates with submicromolar potency ( EC 50 =8-640 nM). PF-3450074 (PF-74) acts at an early stage of HIV-1 infection, inhibits viral replication by directly competing with the binding of CPSF6 and NUP153, and blocks the uncoating, assembly, and the reverse transcription steps of the viral life cycle. CPSF6: nuclear host factors cleavage and polyadenylation specific factor 6; NUP153: nucleoporin 153.

Application

Products | Products > Disease Areas > Infection | Products > Disease Areas > Viral Infection | Products > Signaling Pathways > Anti-infection | Products > Research Areas > Infection | Products > Signaling Pathways > HIV

Product Information

• Catalog No.: HY-120072
• CAS No.: 1352879-65-2
• Molecular Formula: C27H27N3O2
• Molecular Weight: 425.52
• Purity: 98.89%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
• Solubility: ≥ 6.25 mg/mL (14.69 mM); Clear solution
• Availability: In-stock

Source

Original product source