AZD2716

CAS No.：1845753-81-2
Grade：99.9%
Formula：C24H23NO3
M.W.：373.44

Important Notice

This product is a chemical product/pharmaceutical intermediate. It is not a drug, an active pharmaceutical ingredient (API), or a pharmaceutical-grade material. It has not been granted a drug approval number or a Chemical Drug Substance Approval Notice, has not passed drug-related review and approval, and is not manufactured, tested, or released in accordance with pharmaceutical GMP.
This product is intended solely for non-clinical research, process development, quality studies, further chemical processing, or chemical synthesis. It must not be used in drug-product manufacturing, clinical trials, clinical diagnosis, or administration to humans or animals, or be sold, used as an input, submitted for regulatory filing, or released as an API or pharmaceutical material.
The purchaser must not use this product, or supply it to another party, for personal consumption, sports or fitness, weight loss, health supplements, food, or animal feed.

View the full Disclaimer

Overview

AZD2716 is an orally active secretory phospholipase A 2 ( sPLA 2 ) inhibitor. AZD2716 inhibits human GIIA sPLA 2 ( IC 50 =10 nM), human GV sPLA 2 ( IC 50 =40 nM), human GX sPLA 2 ( IC 50 =400 nM), snake venom sPLA 2 ( IC 50 =2 pM), and snake ( Bothrops jararacussu ) Lys49-PLA2-like toxin ( K d =110 μM). AZD2716 inhibits sPLA 2 isoforms IIa, V, X, snake venom sPLA 2 s, and snake venom Lys49-PLA 2 -like toxin myotoxic activity via hydrophobic channel binding. AZD2716 suppresses GIIA sPLA 2 production, neutralizes snake venom-induced myotoxicity, and improves survival in envenomed mice. AZD2716 can be used for the research of coronary artery disease, atherosclerosis, and snakebite envenoming.

Application

Products | Products > Disease Areas > Blood or Cardio-cerebrovascular Disease | Products > Disease Areas > Cardiovascular Disease | Products > Disease Areas > Atherosclerosis | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Research Areas > Cardiovascular Disease | Products > Signaling Pathways > Phospholipase

Product Information

Catalog No.: HY-120078
CAS No.: 1845753-81-2
Molecular Formula: C24H23NO3
Molecular Weight: 373.44
Purity: 99.9%
Storage: Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
Availability: In-stock

Source

Original product source

Welcome！

Please leave a message for us or use the following ways to contact us, we will reply to you as soon as possible, and provide you with the most sincere service, thank you.

NO. 18 ,Wujiang Road, Wulidian Street, Jiangbei District, Chongqing
+86-23-6139-8061 +86-13650506873
danny@chemdad.com sales@chemdad.com
www.chemdad.com
WhatsApp +86-13650506873