SLM6031434 hydrochloride

Overview

SLM6031434 hydrochloride is the hydrochloride salt form of SLM6031434 ( HY-120268 ). SLM6031434 is a highly selective sphingosine kinase 2 ( SphK2 ) inhibitor with an IC 50 value of 0.4 μM for SphK2 . SLM6031434 exerts anti-fibrotic effects by increasing sphingosine accumulation and Smad7 expression. SLM6031434 demonstrates effective anti-fibrotic efficacy in a unilateral ureteral obstruction (UUO)-induced tubulointerstitial fibrosis mouse model. SLM6031434 can be used for the study of proteinuric kidney diseases or chronic kidney disease (CKD).

Application

Products | Products > Disease Areas > Inflammation or Immune System Disease | Products > Signaling Pathways > Immunology/Inflammation | Products > Research Areas > Inflammation/Immunology | Products > Signaling Pathways > SphK

Product Information

• Catalog No.: HY-120268A
• CAS No.: 1897379-34-8
• Molecular Formula: C22H31ClF3N5O2
• Molecular Weight: 489.96
• Purity: 99.1%
• Storage: 4°C, sealed storage, away from moisture * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
• Availability: In-stock

Source

Original product source